They did this by inserting a representative H7 protein coding sequence in between normal NDV genes. The serum collected from mice immunized with this recombinant virus could block a range of H7-containing influenza A viruses. A new vaccine candidate in the making.
Making antibodies cross-react with H7N9.
Prof Peter Palese's group has been busy publishing several papers in the Journal of Virology. One report describes the creation of cross-reactive antibodies to H7N9 by making Newcastle disease virus (NDV; a very contagious bird virus that has already been established as a poultry vaccine backbone) produce the H7 haemagglutinin from North American birds (H7N1-3).
They did this by inserting a representative H7 protein coding sequence in between normal NDV genes. The serum collected from mice immunized with this recombinant virus could block a range of H7-containing influenza A viruses. A new vaccine candidate in the making.
They did this by inserting a representative H7 protein coding sequence in between normal NDV genes. The serum collected from mice immunized with this recombinant virus could block a range of H7-containing influenza A viruses. A new vaccine candidate in the making.
Related Posts:
H5N1 did not transmit easily between humans in the wild...- Pre-existing antibody reactive to avian influenza A(H7N9) virus did not predict better survival
- MERS-CoV antibodies not found in children in 2010-11 or adults from 2012
More MERS molecular masterfulness: Egyptian camels contain lots of anti-MERS-CoV antibodies [AMENDED]
Antibodies in 10-year old UAE camel sera suggestive, but not evidentiary, of the presence of MERS-CoV a decade ago
