Medical News Blog Information

Infection prevention and control and MERS

Harriman, Brosseau and Triverdi have written to the Editor of the New England Journal of Medicine (NEJM) to express their concerns over the lack of apparent preventative measures undertaken during the Al-Ahsa Middle East respiratory syndrome (MERS) coronavirus outbreak communicated by Assiri et al (previously reviewed here).

The new letter indicates that with so little known about MERS-CoV transmission route(s), a safer bet would have been to protect healthcare workers as much as possible. They suggest use of  respirators rather than surgical masks (see Mike Coston's reviews of the differences here, here, here, here and here...likes his masks does Mike). 

Possibly eye protection as well given the transmission unknowns. 

I've previously listed these and other precautions for managing patients with endemic or with less well-defined respiratory pathogens. Worth a reminder read.

The authors highlight it would be prudent, in a well-resourced country like the Kingdom of Saudi Arabia, to roll out as many extra personal protective safeguards for the front-line healthcare workers as possible; at least while the slow hunt to understand how the virus is acquired and transmitted seeks some answers.

The reply to this letter by Memish, Al-Tawfiq and Assiri did not specifically agree with its specifics or address enhanced care for HCWs, instead restating what was done to respond. The key comment summing up the use of respirators indicates a reactive rather than proactive approach to HCW care in trying to prevent a case from spreading their laboratory confirmed infection. 

...putting surgical masks on all patients undergoing hemodialysis and particulate respirators (N95 masks) on any patient with confirmed MERS-CoV who was undergoing an aerosol-generating procedure...

As we've seen over and over again during this outbreak and others, by the time a laboratory confirmation is available, it is far too late to halt early transmission events

When those events occur in a hospital environment it's not just the relatively (to the MERS-CoV case averages) younger and more healthy HCWs that are at risk of infection and disease. MERS-CoV and other respiratory viruses are at their most lethal among the elderly with comorbidities. Delays in lab testing, in waiting for something to happen or in following other's guidelines to the letter rather than modifying or creating new ones based on front-line experiences, can have severe consequences.

I take the message from this letter as: Be proactive not reactive.

MERS-CoV and the host: a serious disease of those with disease

Case total currently stands at 150 including 64 deaths (PFC of 43%), with the World Health Organisation's latest update adding in the recent death (their tally says 149/63) and the Oman case and a new death being reported from eastern Saudi Arabia. The details for this latest patient are (FT#152):
  • 56-year old male
  • Comorbidities
  • Contact of a previous case.
So, as the Oman case showed, transmission from a previous case can lead to mild illness. The Qatari case before that showed that a contact can be asymptomatic. This latest fatality highlights that under the right pre-existing disease conditions, even a 2nd "passage" of virus from a human to another human, can lead result in death. 

It's a very much about the health of the human host who acquires the virus, as we've seen all along with MERS and also among cases of influenza A(H7N9) virus infection.


The latest WHO update also notes that...


Patients diagnosed and reported to date have had respiratory disease as their primary illness. Diarrhoea is commonly reported among the patients and severe complications include renal failure and acute respiratory distress syndrome (ARDS) with shock. It is possible that severely immunocompromised patients can present with atypical signs and symptoms.

New MERS-CoV laboratory test: takes 10-minutes but what can it tell you?

Back in June we heard of a quick test for MERS-CoV to add to the diagnostic armamentarium. I posted on it here.

Now that the Abu Dhabi Medical Congress & Exhibition it was presented at is over, we are hearing about it again through a story at The National. 


Still no details though, so my original concerns about sensitivity (how often will it miss true positive cases because it is not sensitive enough?) linger on.

Further, it's a "blood test" that also uses DNA amplification so the patient will presumably need to be sick enough to have a viraemia (virus spilling over into the blood) so it may not help at all for screening contacts or less ill people with lower viral loads. It is being described as useful for "identifying the virus in its early stages". 

Another assay that looks similar, described in PLoSONE by these researchers earlier in the year, does not appear comparable to PCR-based methods in terms of its sensitivity. 

For MERS-CoV, as for any newly emerging pathogen with unknown characteristics spreading in ways we are yet to understand, detection sensitivity is a key factor.

I look forward to seeing same real-world evaluation data.

French "probable" case pas vraiment so probable after all

FluTracker's and Mike Coston is busy keeping us up-to-date on the latest with MERS-CoV concerns around the world post-Hajj.

Last night's probable case has tested negative for the MERS-CoV according to media - the Health Ministry website has not released this yet.

The surviving case of MERS-CoV in France, is still hospitalized.

First case of MERS-CoV in Oman...home of antibody-positve camels...[UPDATED]

A new country has described, via the media (quoting Mohamed bin Saif al Hosni, Under-Secretary for Oman's Health Affairs), its first Middle East respiratory syndrome coronavirus (MERS-CoV) case, the sultanate of Oman. 

It seems that the case was acquired locally from someone infected outside Oman.

  • 68-year old male with diabetes
  • Still no detail on the supposed confirmed case he was in contact with or the test type or date of hospitalization
  • The Oman Ministry of Health website has not officially confirmed the case at this stage. 
  • When confirmed, this will be the 149th confirmed case ("probable" FluTrackers #151)

Oman's Centre for Public Health Laboratory (CPHL) has been testing for MERS-CoV from suspect cases since October 2012 and while prospective laboratory screening of returning Hajj pilgrims was not being undertaken, observation for signs and symptoms of disease was ongoing.

If we remember back to early August, - 50 of 50 retired racing camels from Oman had antibodies to something that was closely related to the MERS-CoV. 

Thanks to Mike Coston, @makoto_au_japon and @Crof for tweets and posts
Thanks to FluTrackers for tweeting & posting the AFP updat

Latest confirmed cases and a probable new MERS-CoV case(s) in France [UPDATED]

It's been a couple of days since the last report of a new MERS-CoV case, that of an expatriate, 23-year old asymptomatic male contact of another case in Doha, Qatar (the 7th seemingly acquired on Qatari soil). 23M (FT#150) was mildly ill and was diagnosed through routine screening of contacts. The man worked with animals in a barn owned by a previous case according to the latest WHO update. Once again this highlights that the MERS-CoV can move on from an infected person and it can do it stealthily. However, the next "round" of infection seems to be (a) milder in severity and (b) the end of the transmission event.

Unfortunately the recently described MERS-CoV-positive 83-year old woman in Jubail on the eastern coast of Saudi Arabia, has reportedly died. Apparently she was hospitalised a month ago.


Buzzing around on Twitter (thanks to @makoto_au_japon) and the web nothing is the story of a probable case in a 43-year old in France. The man returned from a stay in Saudi Arabia and he is currently described as stable. There areno more details on France's Department of Health and Social Affairs website but they have noted it on their Twitter feed (@Minist_Sante) and have the media release. The various translations mention the plural, "cases" (machine glitch?). An article in the Khaleej Times notes it is unclear whether this person was a pilgrim to the Hajj. My Form 3 French is very rusty and didn't covered public health so I eagerly await laboratory confirmation. 


If this imported case is confirmed [UPDATE: it was not] it will be France's 3rd detection, only 1 of which has been transmitted locally.


The MERS-CoV laboratory confirmed count currently stands at 148 cases with 63 deaths (PFC of 45.6%) .

Alaska, USA - Isaac Benowitz, Resident in Pediatrics, Massachusetts General Hospital - Health Disparities of Alaska Natives

September 12, 2013

Access to water has been described as a basic human right. I'd heard plenty from my medical school classmates about the challenges of bringing water to poor villages scattered across Africa but I didn't realize there were places in the US with similar challenges, places where water isn't taken for granted.

I'm out in rural Alaska, "the bush," far away from the "big city" of Anchorage (which at 350,000 has half the state population). I'm in Bethel, Alaska, population 6,000 people and probably as many dogs, all-terrain vehicles, and snowmobiles (or "snowmachines" as they're called here). I've spent the past few days here working with the environmental health team of the regional native health corporation that provides for the health needs of 25,000 people, mostly Alaska Native, spread out across 50+ villages and communities in an area the size of Oregon. This is a tough place to live for the mostly poor native populations in the rural villages. They lack the oil that brings wealth to villages much farther north, and the fishing and tourism that are prevalent in many other parts of the state. Access to clean water for sanitation and cooking is one of the basic challenges out here.

Most of the villages out here historically had third-world rates of invasive bacterial diseases: pneumococcal pneumonia, haemophilus influenzae meningitis, and soft tissue infections, until not long ago. Vaccines made some headway but that's an incomplete solution. In areas where piped water has been brought in, disease rates dropped much farther. There has been a push to improve the access to basic sanitation, to provide better access to plentiful clean water and disposal of sewage, but the implementation is a persistent challenge. There's plenty of water out here at least in some places, in the rivers and lakes and the ocean, but it's expensive to treat and difficult to transport to houses. The Arctic provide some tough obstacles: the ground in this whole region is soggy and unstable and so it can't maintain water pipes, and anything above ground is incredibly expensive to keep warm when the nighttime temperature hovers in the single digits (Farenheit) for 3-4 months of the year and record cold weather dips to -45 F. Sewage disposal faces similar challenges (and freezes a lot harder than water). Supplies to the region come by cargo barge up the river, or by cargo plane, during the short summer here; in the winter, the rivers freeze solid enough that people can drive on them with snowmachines and light trucks but cargo can only come by plane. The area is rich in fish and berries but poor by most other measures. The regional health corporation is quite proactive, though, and has worked with the state and the individual cities and villages to get better sanitation to the people here. In the past, a village would have a central water distribution plant where people filled small jugs and transported them home by foot, all-terrain vehicle, or snowmachine; human waste was collected in a "honeybucket" and then dumped in each neighborhood and then towed to the village sewage lagoon.

There is an on-going initiative to bring piped water to every home in Alaska, and it faces an array of uphill battles in places like the YK Delta where many people live in villages with only a few dozen people, and the nearest real infrastructure is 20 or 50 miles away with no roads in between. Several years ago an ambitious project installed water tanks, low-flow toilets, and sinks in most of the houses in a handful of villages, using all-terrain vehicles in the summer and snowmachines in the winter to haul water to homes and haul sewage away to nearby lagoons. And they disassembled any remaining infrastructure supporting the older systems that were phased out. The system was great in principle but it has problems. The first is that over the years we've learned more about the amount of water the people use on a daily basis for what we'd consider a modern lifestyle, and we've also learned a lot out here about the economics of water utilization. And it turns out that at the price point that this water is available, and the quantities in which it's delivered, there isn't nearly enough water coming into these homes to really use water the way we all do in our homes. There's enough water to cook food. There's running water in a bathroom and a sink and a toilet, but people ration water by putting a bowl under the sink and reusing the water several times. People have simple agitation clotheswashers and it's quite common to run 5-6 loads of clothes in the same water until it turns grey or black.

I spent the last two days on a house-to-house survey of these failing water systems in a small village in the YK Delta. More recently, some of the villages with this "flush tank and haul" system have run into some serious maintenance problems that are, at some level, representative of everything wrong with these novel solutions to the water challenges out here in bush Alaska. The toilets in these homes, low-flow toilets purchased at great cost from Japan to reduce water use, are failing in simple ways, and there are no repair parts here. (Apparently the toilet flush handles were made in a factory in Japan that fell in an earthquake, and it's not clear that anyone is making more replacement parts now.) There are some repair parts floating around but people are unwilling to pay steep prices to make repairs to a system they never totally bought into in the first place. The toilets flush sewage to tanks outside the homes and workers pump out the sewage to transport to a lagoon, but the pipes that connect the homes to the tanks are falling apart. In many instances they've frozen in the winters leading to more severe damage. When people stop using this tank system, they start dumping sewage anywhere (next to their homes) which is pretty unsightly and it also means that there aren't as many fees pouring in to support the system that remains. We found all the problems that I've described above, and a village with limited means to repair a failing system. After I leave, the rest of the team will work with the village and the community to find ways to repair the system, but it's not clear where that funding will come from (this system probably cost $5 million for a village of a few hundred people, but there's no repair fund leftover) and it's not clear whether this system is viable long-term.

On a small scale, the fixes are easy in villages like the one I visited: find a repair person, find funds to pay them to get the system running again. There are other villages nearby where there's more funding, and maybe two or three people that know how to do the maintenance work, and things work better. But on a larger scale, though, the water and sewer system in that village is probably destined to fail because what made sense a decade ago no longer seems sustainable and maintainable. The state is sponsoring the "Alaska Water-Sewer Challenge," inviting bids from around Alaska, and around the world, for the next greatest system, or set of systems, to tackle the complexities of bringing adequate supplies of water, and adequate sewage removal services, to all these small remote communities. It's frustrating and disturbing to find entire communities in the US that we haven't managed to bring up to modern sanitary standards. As I head back to Anchorage and then back to Boston in a few more days, I leave with a sense of hope. There are big challenges here in Alaska, with providing basic services to these remote villages, are big challenges. But I also met a lot of highly-motivated, dedicated people, young and old, Alaskan and from elsewhere, here working to address these health disparities, and I'm hopeful that they'll persevere, with more initiatives and iterations, and see progress in our lifetime.

And as I head home, I'm incredibly grateful to all the people and organizations that made it possible for me to come out here, learn about all these challenges, and help think about how to address them. Thank you to Tom, Ros, Mike, Prabhu, and others in CDC's Arctic Investigations Program for letting me join them for the month. Thank you to Jenni at the Yukon-Kuskokwim Health Corporation for the opportunity to head into the field and learn about environmental injustices on the American frontier. Thank you to MGH Pediatrics for letting me slip away for a month. And thank you to the Partners Center of Expertise in Global and Humanitarian Health program for financial support of my travels!

With limited water coming into each home, people ration water by putting a bowl under the sink and reuse the water.
The village spigot. This village is large enough to have centralized water treatment, but with soggy ground that can't support pipes, and freezing temperatures that make above-ground pipes a recipe for freezing, they rely on ATVs and snowmobiles to carry water to each home and haul sewage away.

Going house to house to survey the state of the "flush tank and haul" systems in a small village in rural Alaska.
Heading back from a village visit, by small motorboat on one of the winding rivers in Alaska's YK Delta.

Alaska, USA - Isaac Benowitz, Resident in Pediatrics, Massachusetts General Hospital - Health Disparities of Alaska Natives

August 26, 2013
Greetings from America's frontier! I�m spending a month in Anchorage, Alaska, working with the CDC�s Arctic Investigations Program. I came to pursue some interests in the social determinants of health and environmental health, chasing an opportunity to work alongside CDC researchers who study health issues in Alaska Natives and other Arctic populations and to dabble in some of the diverse applied public health and epidemiology projects going on here. Alaska has a population of 700,000 people, including about 150,000 Alaska Natives, a term that describes people from several different tribes. Some people of native heritage live in urban settings and have a health status similar to others in modern cities, with relatively good access to clean water, clean air, access to healthcare. But there�s also a huge native population living in small remote rural villages where they rely on subsistence fishing and hunting and gathering, live in simple homes that often lack adequate ventilation of wood stove fumes or running water and sewage services, and have fairly poor health status. A small, cramped home makes sense way out there, despite all of the available land, when you're thinking about the heating bill for the long and harsh winters up here with prolonged stretches of sub-freezing temperatures. It�s disturbing, and amazing, to find places in the United States without abundant clean running water in homes, but there are several villages where there is no public water supply, or that supply is a pump across town, or there is an infrastructure to distribute clean water to homes but people can�t afford the bills. These villages have experienced very high rates of invasive bacterial diseases: Haemophilus influenza, meningococcus, strep pneumoniae, and skin and respiratory infections from staph aureus, as well as tuberculosis in some places, but gains in vaccination rates have turned the tide on much of this. Diets are a mix of traditional foods (think about lots of heavily-preserved fish and game meat... and the occasional whale feast!) and more modern foods brought in from outside. Transportation is a mix of boats on rivers in the warmer months and snow machines (snowmobiles) in the long winters.

I have a few projects to jump into for my time here, in addition to getting a flavor for other work in progress here. This research group at CDC works closely with the Indian Health Service, a federal agency that provides healthcare to native populations across the US, including Alaska Natives here in Alaska and American Indians elsewhere, in their own clinics and hospitals and as an insurance provider. There has been an observed rise in rates of hospitalizations in Alaska but nobody has taken a big-picture look at the IHS hospitalization data to examine trends by year and by diagnostic category, so I'll be pursuing some health services research analyzing hospital admission data. Next, there is a long-observed increased burden of skin and soft tissue infections in the Yukon-Kuskokwim Delta, a region of Southwest Alaska the size of Oregon, with 25,000 people scattered across 50 rural villages with most populations under 1,000. We know that much of this is related to poor overall health status (similar scenarios have been studied in indigenous groups in Canada, Australia, and New Zealand) but the challenge is finding workable ways to reduce the significant health burden of these skin infections. Prior field investigations and studies identified several factors that contribute to boil development, including overuse of antibiotics for respiratory conditions (leading to the development of resistant strains), poor general hygiene (many people shower once a week, with no soap) and communal steamhouses (tiny sweat lodges, build from plywood, where as many as eight people may cram into one sauna session) that allow for skin-skin contact and biofilm formation which both predispose to MRSA transmission. The regional health corporation (like the county health department for the tribal population) asked CDC to recommend ways to reduce the burden of MRSA carriage and boil development; I�ll be helping to select intervention strategies and conduct environmental testing to let us better define MRSA transmission dynamics. CDC is also pursuing several projects related to the burden of human papillomavirus (HPV) ranging from studying virus stereotypes in tissue samples to starting a vaccine effectiveness trial for HPV in native teens (the effectiveness will depend on whether the same strains are prevalent up here as in the rest of the US), looking at titer levels in teenagers over several years, and if I have time I�ll help recruit teenagers into this study designed to determine whether the three-dose vaccine series works as well in the Alaska Native ethnic group as it does in other populations where it�s been studied.

And in the time that remains, I hope to explore a few parts of Alaska. It�s gorgeous in Anchorage this time of year (August-September), a little rainy mixed with some sun, but with temperatures in the low 60s and long days with an evening glow that lingers for hours before the sun dips over the mountains around 9pm. Many people who live here love fishing in the rivers and in the ocean, hunting, boating, cross-country skiing, hiking, and running. It�s not just people in rural villages who value subsistence: one researcher here explained that it�s so easy to live off the land, so easy to fish, hunt, collect berries, and grow vegetables in a garden in the short growing season, that Alaskans consider it an indignity to go to a market for any of those foods instead of diving into their deep freezers.


 Arctic Investigations Program is CDC's outpost on the American frontier.

Every presentation from the CDC Alaska group had a picture of a moose, so here's mine.

It's gorgeous in Alaska in late August. Here's a wildflower on a hike a few hours outside Anchorage, with a high mountain stream in the background.

Why palm tress in the MERS-CoV acquisition model...?

Click to enlarge. See more at earlier post.
I have palm trees drawn in as a sort of focus for my hypothetical acquisition model for the Middle East respiratory syndrome coronavirus (MERS-CoV). 

I first posted this graphic back in late August. It shows ways in which humans might acquire/have acquired the (probably) occasional MERS-CoV infection from an (suspected) animal host/intermediate host.


You can probably see from that paragraph, that this is just some crazy thoughts and there are no data that link them together.


I was recently asked why the palm trees? My thinking here was that date palms, and perhaps other flowering trees, may attract insectivorous bats as well as providing shade, and perhaps water if nearby, for animals and humans. This could create a point of cross-over between species - even if they don't directly co-mingle there may be opportunity to come in contact with contaminated excreta, saliva or partially eaten fruit or bugs.

Influenza deaths amongst children...



Influenza-associated paediatric mortality data.
US CDC FluView. Click to enlarge.
I'm a little bogged down in feeling sorry for myself (no new grants in 2013), paper writing, grant planning/duck aligning just now - but I'm keep an eye on Twitter for gems like this one.

Over on his blog, Avian Flu Diary, Mike Coston has a great summary of some papers and a recent study that serve to highlight the importance of vaccinating children against influenza virus. It's a virus that can kill especially among, but not limited to, those with comorbidities. Influenza is a vaccine-preventable disease.

Have a read of the whole article at http://afludiary.blogspot.com.au/2013/10/pediatrics-influenza-associated.html.

Harare, Zimbabwe - Jessica Magidson, Postdoctoral Fellow, Chester M. Pierce, MD Division of Global Psychiatry, MGH - Improving depression and HIV medication adherence for health care workers



Greetings from Harare, Zimbabwe (or �Mhoro� in Shona� I�ve been slowly trying to learn Shona, the most commonly spoken language in Harare). I am here with Dr. Conall O�Cleirigh, a mentor of mine in the Psychiatry Department and Behavioral Medicine Service at MGH, and our gracious hosts, Dr. Melanie Abas, Dr. Frances Cowan, and Dr. Dixon Chibanda from King�s College London and University of Zimbabwe College of Health Sciences (UZ-CHS).




We are here leading a three-day training at UZ-CHS to train health care workers on brief, empirically-supported behavioral interventions for improving HIV medication adherence. Adherence in this setting is crucial, as in addition to consequences of HIV medication nonadherence that we see in the U.S. (lower levels of viral suppression, accelerated disease progression and mortality, production of medication-resistant HIV strains, and potentially greater likelihood of HIV transmission to others to name a few), there is also a reality here that when individuals fail first-line antiretroviral therapy (ART), there may be limited ART treatment options. As a behavioral intervention to improve ART adherence in this setting, we are focusing on Life-Steps, a single-session cognitive behavioral and problem-solving-based intervention for improving medication adherence. Life-Steps has been developed and tested by MGH faculty (Safren et al., 1999) and implemented in international contexts, including South Africa, although this is the first formal training and implementation in Zimbabwe, and modifications have been made for this setting.   

Day 1 of the training was a larger training � �master class� � open to a wider group of students, health care workers, and faculty as part of a capacity building initiative �Improving Mental Health Education and Research Capacity in Zimbabwe� (IMHERZ). This initiative focuses on bringing together leaders in global mental health and capacity building expertise from partnering institutions primarily in South Africa (University of Cape Town) and London (King�s College London) to increase availability of academic training in Zimbabwe as well as to offer exchange opportunities with partnering institutions. We were invited to teach a 3-hour �master class� to present the current state of the science on behavioral interventions for improving ART adherence and train the group in Life-Steps specifically. Prior to the training, we received input and feedback from local providers and faculty regarding how to culturally tailor the material to make the training as relevant as possible for the Harare context. There were over 60 people in attendance across numerous disciplines, and a few clinical psychologists in particular emerged as leaders within the group to aid in the tailoring and teaching of the material. That evening, the IMHERZ team held a dinner for us at a private home � we had a feast of Ethiopian food and the discussions continued. 

Dr. O'Cleirigh leading a role play during the IMHERZ master class


The second two full days of clinical trainings were conducted with a smaller group of health care workers (ART adherence counselors and in-training psychologists) and psychiatry department faculty. This part of the training was to provide more hands-on instruction and supervision for local providers who will be beginning to implement these interventions in local ART prescribing clinics, as well as guidance for the psychologists who will be supervising the providers. In addition to continuing a more in-depth and hands on training of Life-Steps, we discussed specifically the way in which symptoms of depression interfered with medication adherence, and how brief, empirically supported treatments for depression could be delivered alongside ART medication adherence interventions. Specifically, we trained the counselors briefly on behavioral activation (BA) for depression and problem solving therapy (PST) � although this proved to be, in my perspective, the most challenging part of the training.

Discussion of local barriers to ART adherence (listed on the board) with local students in attendance and our host Dr. Melanie Abas
One of the key challenges that emerged was that there did not seem to be a consensus for a term for �depression� in Shona. There is a well-documented clinical phenomenon in Zimbabwe called �kufungisisa,� which translates as �thinking too much� -- this was actually just included as a �cultural concept of distress� in DSM-5, the version of the Diagnostic and Statistical Manual of Mental Disorders released in 2013. In some cases kufungisisa has been seen as synonymous with the manifestation of depression in this culture, yet upon further discussion within our group of psychiatrists, psychologists, and health care workers during this training, it became unclear if kufungisisa always reflects a true clinical depression. We had fascinating discussions as a group as how to distinguish when kufungisisa reflects depression, or when it�s a normal human experience given the context of immense psychosocial stress, poverty, and violence. It also emerged that the ART adherence counselors who we were training (with no previous mental health experience or training) identified �stress� and their notion of �depression� as being synonymous. Although the DSM and our training in psychiatry and clinical psychology routinely and importantly make this distinction, I began to wonder how important these distinctions were in this context for our training and for the delivery of empirically supported interventions in this setting, when in fact many of the intervention techniques are effective across stress and depression, and both of which can interfere with adherence. We had to strategize at this point what would be the most efficient and effective focus for our remaining training sessions. 
With our host and the team of adherence counselors and supervisors who were trained in Life-Steps and will be implementing Life-Steps in local ART prescribing clinics
 





In addition to these challenges surrounding how to discuss and treat depression, the training in Life-Steps lasted much longer than anticipated � primarily due to challenges in re-orienting the adherence counselors from their previous approach to counseling to a more structured, cognitive-behavioral therapy (CBT) approach, which is problem-focused and time-limited. We found that the adherence counselors were trying to tackle numerous problems beyond just aiming to change adherence � how to solve their patient�s impoverished situation, lack of condom use with uninfected partners, domestic violence, etc. � leaving very little time to discuss the actual treatment goal: adherence. This approach of focusing primarily and solely on barriers to adherence was a huge shift for these providers. Additionally, adherence counseling in this setting previously was seen to be more �authoritative,� with adherence counselors often using a �wagging finger� to demand that their patients take their HIV medications, as opposed to a more non-judgmental, motivational approach typically used in CBT. Training this shift into CBT proved to be a challenging, yet doable endeavor.

In discussing with local providers, our faculty hosts, and the adherence counselors being trained, we decided to spend time conducted in-depth role plays of the treatment techniques, with myself and Conall demonstrating first and then the adherence counselors role playing the same techniques. We did role plays first all in English and then in Shona, and the supervisors in-training led this session. Interestingly, observations emerged that some of the words we had been using in the English role plays needed to be modified for Shona; for example, �why did you not take your medication� was interpreted as accusatory and blaming in Shona. The feedback was to generate other ways of asking this question without the word �why.�

We saw tremendous progress over the course of the 3 days in seeing firsthand the adherence counselors implementing these new techniques � setting agendas, discussing motivations for taking medications, supporting imperfect adherence and developing a non-judgmental context for treatment � along with structured problem solving techniques. The adherence counselors will begin implementing these techniques next week at the local ART prescribing clinics. Prior to the training, the counselors were videotaped doing role plays, and these will be re-done in one month with a supervisor coding and rating based upon a Life-Steps treatment fidelity checklist to see whether these changes are evident and sustain one month following the training. We hope to disseminate this experience and the results to the larger scientific community given the challenges often faced and the need for trainings in these types of settings.

On our final morning in Harare, we had a research meeting to guide discussions of a future randomized clinical trial to evaluate these techniques in comparison to usual care and to ultimately improve the treatment of depression and HIV medication adherence among individuals living with HIV in Zimbabwe � known as the �Treatment to improve depression and adherence to antiretroviral therapy in people living with HIV in Zimbabwe,� (the �TENDAI� study). We discussed issues related to the design, other methodological and assessment measurement issues, how to continue to implement supervision, training, and guidance in this process from the U.S., and planning for future visits to Harare.

We believe this work is truly meeting the IMHERZ initiatives through implementation of a local curriculum open to local mental health faculty, providing opportunities for training individuals to later train other providers, ongoing clinical supervision and support for research methodology, as well as to cultivate collaboration through the partnering institutions. One of the key objectives of IMHERZ is to set up ongoing collaborations with University of Cape Town (UCT). From Harare, I will be flying to Cape Town, South Africa to meet with UCT faculty involved in IMHERZ and the TENDAI study who have a specialized focus on adherence and depression in HIV. In addition to discussing the TENDAI study, we will also be discussing opportunities for collaboration for other clinical research projects to conduct during the fellowship with my global psychiatry mentor Dr. Steve Safren. More to come from Cape Town!
Our hosts insisted we see the beauty of Zimbabwe and took us to Lake Chivero just outside Harare... luckily white rhinos aren't dangerous!

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