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Anesthesiology Lessons for Rwandan Residents: Troubleshooting Intraoperative Hypoxemia from the Lounge of a Luxury Hotel


How does a country with 13 anesthesiologistprovide anesthesia care for a population of 12 million? In Rwanda, since 1997, anesthesia technicians have provided anesthesia in the operating theater after undergoing a 3-year training program, which they could enter from high school. Prior to the initiation of the first anesthesia residency class in Rwanda in 2006, the country had only 3 physician anesthesiologists who were trained in France and Belgium. The lack of any educational infrastructure prior to independence from Belgium in 1962, and the long-standing ethnic conflicts between the Tutsi�s and Hutu�s have hampered the development of medical care and education system. However, though in its ninth year of operation, the anesthesia residency program currently has only 9 out of its 24 positions filled. In sharp contrast to the rising popularity of anesthesiology as a career choice in the U.S. and Canada, few medical graduates in Rwanda choose anesthesiology due to a combination of high-stress, disproportionate patient morbidity and mortality, low salary and long hours, and excessive clinical and administrative burden.
With this dire shortage of physician anesthesiologists, the clinical role that these residents are expected to fill is utterly different from the role that I, as an anesthesiology resident in the U.S., am trained to fill. Rather than directly providing the anesthesia care, the Rwandan anesthesiologists will be mostly acting as consultants to the anesthesia techs. Currently, the techs could discuss complicated cases with the anesthesiologist on call, and can phone them when problems arise. Consequently, the residents infrequently take responsibility for a case from beginning to end. As well, with the responsibility to take overnight ICU calls, the residents are in the operating theater only about 2-3 days a week. This severely limits their intraoperative training and exposure to the infrequent but high acuity events that require rapid troubleshooting, diagnosis, and decision-making.
A key aspect to highlight is that with the shortage of physician anesthesiologists, in the absence of foreign anesthesiologists, the anesthesia residents would be learning anesthesia mainly from books and the anesthesia techs. This is an educational gap that the U.S. physicians working in Rwanda through the Human Resources of Health (HRH) collaborative have filled. The anesthesia techs perform a very admirable job of placing thousands of patients under general anesthesia and bringing them safely through surgery, especially for patients with advanced stages of disease and uncontrolled comorbidities that anesthesiologists in the developed world are mostly shielded from. However, without having been through college or medical school, they lack the fundamental understanding of physiology and disease processes that would alert physicians to perform more thoughtful preoperative investigation and optimization, and to manage the intraoperative and postoperative course. This became evident when I went with a U.S. attending anesthesiologist and the local resident he is paired with to the wards to evaluate patients with inexplicably high blood pressures, possible untreated heart failure, or pulmonary problems. Although the anesthesia techs had already performed a preoperatively evaluation of each patient the evening before, we felt strongly that further optimization and discussion with the primary team was necessary and postponed the cases. Thus, a critical aspect of the U.S. physicians� interactions with the anesthesia residents is encouraging them to apply their medical education and years of practice as a general practitioner to think and act as a physician.
Under these circumstances, simulation is a critical component to the residents� didactics to create opportunities for making managing complicated or emergency scenarios. However, the simulation center was recently shut down due to lack of funding for a managerial administrator. Also, as commonly happens to expensive equipment sent to developing countries lacking the technical support for maintenance, the SimMan requires repair and can function now only as a low-fidelity mannequin. Thus, instead of designing a classical intraoperative scenario, I designed cases where the residents were called on the phone to help an anesthesia tech manage an intraoperative event. Considering the role of anesthesiologists as consultants, not using the SimMan actually better approximates their future responsibility.
Another unanticipated challenge of simulating the case was relocating our class at a moment�s notice to the lounge of a hotel. We learned just when class was about to begin that no room was available at the college due to exams. This experience in teaching anesthesia in a low-resource country has challenged me to identify educational and knowledge gaps through careful observation, to tailor lessons to local practices, and to be flexible in adjusting to surprise circumstances. Thankfully, the two first-year residents I worked with were very obliging, and engaged fully in the scenario. Meanwhile, we were able to enjoy the perks of having class at a 5-star hotel � high-speed wifi, plush couches, and fine Rwandan coffee.

Editor's Note #23: Tweepidemiology#2..

Thought it was time to update the "Tweepidemiology" graph I first posted back in September of 2014.

The Ebola virus disease epidemic of 2014 certainly drive the biggest of my Tweepidemics.


Followers of my @MackayIM Twitter account (and this blog which gets
promoted through it) since I started tweeting.
This shows the cumulative rise, and pause, of followers and the relationship between the rate of that rise and some active periods of infectious disease outbreaks..
Click on the graph to enlarge

This will be something I check back in on from time to time. Interesting stuff. 

As above but zoomed in to show the dip in followers of the @MackayIM Twitter account.
Click on the graph to enlarge.
Something else this little analysis showed me was still interesting, but very disappointing. That thing was one of the biggest losses of followers and slowest periods of follower gains that my Twitter account has had in its 2 years. 

This dip happened immediately after I changed the background on my avatar to reflect my support for the US Supreme Court's legalisation of same sex marriage. I kept that background for a week. I haven't been able to find anything else to attribute to the dip - I haven't been any more annoying or rude than I usually am! I don't blog to gain followers per se but followers are very helpful because they help spread sometimes useful information further than it might otherwise reach. Also, because you're mostly a likable bunch of course! In the scheme of things it was a blip - and there is always a turnover of newcomers and "newleavers" and the latter generally increases in proportion to a decrease in my level of engagement. It just strikes me as sad that people feel so much dislike or annoyance that they need to respond by leaving the table in disgust or annoyance like a child who doesn't get what they want.

Data. So many things to learn from them.

Editor's Rant: Communicating the data and about the data...

It is pretty damn hard work trying to get hold of data on virus outbreaks around the world. 

When it is, it may be available in unfriendly formats. It may not be made public at all. When it is available, it is often slow to appear or it may have random reporting gaps, or be partially incomplete. The style of the released data can change overnight as well, sometimes going from detail to summary.

So why bother about trying to get hold of these numbers at all? It's not like I work in the field. Well, that is a question I'm increasingly asking myself of late too. My personal reason has been because I think there need to be more voices in the vacuum between the numbers being reported and the often dry public health reports. I think scientists, even if they are not lifetime experts on a given virus or outbreak, still have much to offer when they come out from behind their manuscripts and apply their skills to interpreting what's happening. Well, many do anyway. And they should do it more. Now, perhaps more than ever, science needs steer away from its cold, dense and boring niche writing to a chattier, more helpful and community-based style of engagement. It astonishes me how often the public's interpretation of outbreak numbers must come from the media or from hobbyists, or even professionals who work in other areas and give of their own time to help explain something to us in their personal time. Helpful and engaging information and better access should come from the source of the data.

So it becomes really annoying (you would have to know me quite well to know how many times I just rewrote those words) when data are given out for public use that are a total mess...and there is not one tiny mote of explanation for it. I called it appalling on Twitter tonight. And at other times there are no explanations for why there are gaps, why data are delayed, why the format may have changed today compared to last week, why a line list is missing a case, using a new and totally independent numbering scheme or suddenly reshuffled, why there is no news about a new outbreak. No word. No contact. No-one taking the lead. No...communication.

I have met a lot of people since I have been blogging who, in various ways, have put in their own personal time to help out bigPublicHealth, to help take up the slack in communicating to the media and to the public. It is hard to quantify the impact of that combined help-but I can assure you that it reaches far and wide and is not insignificant. One would think that it should be easier to provide this help when one is willing to make use of their own time and use their own resources, or that those people should be shown enough respect to be able to simply find and apply reliable raw data so they can help out. But one would be an idiot. I very clearly remember a time when I could send a public Tweet to WHO's Head of Public Relations, Gregory Haertl, and get an informed reply. Those days have passed. I remember there being an #AskEbola channel on Twitter that gave answers. That engagement is just not there anymore. I'm sure its funding and resources and blah blah...but not as sure as I could be if that were spoken about in public. Communication. Someone needs to step up on this. As the quotes above allude to, 2015 is not 2014. And one of those differences is that everyone wants timely and comprehensive information they can rely on during times of outbreak. This hasn't been discusses enough but it should be.
 

Ebola virus: wild and domestic animals, plants and insects...

Initial Ebola virus (EBOV) infection of humans is a rare zoonotic spillover event.  

Hypsignathus monstrosus, Epomops franqueti and Myonycteris torquatebats, all fruit-eating megabats of the familyPteropodidae, are considered to be important reservoir hosts, yet they do not show signs of disease.[1] 

While a great deal remains unknown about the identity and spectrum of natural ebolavirus hosts,[1] zoonoses appear to co-occur with bat pregnancy.[2]


Animals that have died from ebolavirus infections include:[3,4]

  • Duiker (Cephalophus sp.; an antelope) 
  • Gorilla (Gorilla gorilla) 
  •  Chimpanzee (Pan troglodytes)

Living animals found to harbour ebolavirus RNA include:[1,4,23]

  • Cynomolgus macaque monkey (Macaca fascicularis; RESTV) 
  • Franquet�s epauletted fruit bat (Epomops franqueti; EBOV) 
  • Hammer-headed bat (Hypsignathus monstrosus; EBOV) 
  • Little collared fruit bat (Myonycteris torquata; EBOV)
Those animals with only antibodies to EBOV in the absence of infectious virus, suggesting past exposure include:[5,6]

  • Domestic dogs (Canis lupus familiaris
  • Peter�s lesser epauletted fruit bat (Micropterus pusillus; fruit-eating) 
  • Angolan free-tailed bat (Mops condylurus; insect-eating) 
  • Giant roundleaf bat (Hipposideros gigas; insect-eating) 
  • Egyptian fruit bat (Roussetus aegyptiacus; fruit-eating) 
  • Geoffrey�s rousette (Rousettus amplexicaudatus; a bat species; fruit-eating) 
  • Lord Derby�s scaly-tailed squirrel (Anomalurus derbianus)

Porcupines (Hystrix cristata) have been implicated as a source for human EBOV exposure but virus-positive animals have not been documented.[4] 
Between nine and 25% of 337 domestic dogs from various towns and villages in Gabon during an EBOV outbreak in 2001-2002 were identified as possible hosts for EBOV when found to be seropositive.[7,8] It was not known when they became seropositive nor has it been experimentally determined that dogs are able to host an active EBOV infection.[9,10] Dogs were observed in contact with suspected virus-laden fluids and with other animals during the Gabon outbreak but seropositive dog specimens did not contain EBOV antigen or viral RNA. Three specimens from these seropositive dogs did not yield infectious virus in cell culture either and thus there remains no documented evidence for a canine source of human EBOV infection. In 2014, two dogs owned by human cases of EBOV/Mak in Spain (euthanized without testing [11]) and the United States of America (tested negative for EBOV[12,13]) did not exhibit any signs of disease. 
Domestic pigs have been found to be a natural host for the Reston ebolavirus[9,14] and antibodies to EBOV have also been found in guinea pigs, an animal that can also be experimentally infected.[15] Domestic dogs and guinea pigs appear to become infected without symptoms.[6,7] Horses, mice, guinea pigs and goats have been experimentally inoculated with EBOV to produce antisera or test therapeutic preparations.[16,17] 
Pigs experimentally infected with a member of the Zaire ebolavirus become symptomatic.[8] NHP, guinea pigs and mice have been used to examine aspects of disease progression and exhibit various degrees of disease when experimentally infected.[18,19] 
On a few occasions in one study into possible hosts, a low viral load of EBOV could be sporadically recovered after inoculation of a snake (up to 11 days post inoculation), a mouse (up to nine days later) and a spider (21 days later) but the authors of this study concluded that these results could have represented residual inoculum.[21]
Plants, arthropods, cows, cats and sheep have not been found to naturally carry or host ebolavirus infection but only small numbers of some species have been examined.[3,20-22]

References...


    1. Leroy EM, Kumulungui B, Pourrut X, et al. Fruit bats as reservoirs of Ebola virus. Nature 2005;438:575-6. 
    2. Plowright RK, Eby P, Hudson PJ, et al. Ecological dynamics of emerging bat virus spillover. Proc Biol Sci 2015;282:20142124.
    3. Olson SH, Reed P, Cameron KN, et al. Dead or alive: animal sampling during Ebola hemorrhagic fever outbreaks in humans. Emerg Health Threats J 2012;5
    4. Lahm SA, Kombila M, Swanepoel R, Barnes RF. Morbidity and mortality of wild animals in relation to outbreaks of Ebola haemorrhagic fever in Gabon, 1994-2003. Trans R Soc Trop Med Hyg 2007;101:64-78.
    5. Marsh GA, Haining J, Robinson R, et al. Ebola Reston virus infection of pigs: clinical significance and transmission potential. J Infect Dis 2011;204 Suppl 3:S804-9.
    6. Gonzalez JP, Herbreteau V, Morvan J, Leroy EM. Ebola virus circulation in Africa: a balance between clinical expression and epidemiological silence. Bull Soc Pathol Exot 2005;98:210-7.
    7. Allela L, Boury O, Pouillot R, et al. Ebola virus antibody prevalence in dogs and human risk. Emerg Infect Dis 2005;11:385-90.
    8. Weingartl HM, Nfon C, Kobinger G. Review of Ebola virus infections in domestic animals. Dev Biol (Basel) 2013;135:211-8.
    9. Stansfield SK, Scribner CL, Kaminski RM, Cairns T, McCormick JB, Johnson KM. Antibody to Ebola virus in guinea pigs: Tandala, Zaire. J Infect Dis 1982;146:483-6.
    10. Connolly BM, Steele KE, Davis KJ, et al. Pathogenesis of experimental Ebola virus infection in guinea pigs. J Infect Dis 1999;179 Suppl 1:S203-17.
    11. Why Dallas Won't Kill The Dog Of The Texas Nurse With Ebola. Business Insider, 2014. (Accessed 27/4/2015, at http://www.businessinsider.com.au/what-will-happen-to-dallas-nurses-dog-2014-10 )
    12. Starting today, Dallas Animal Services will begin testing Nina Pham�s year-old dog Bentley for Ebola. The Dallas Morning News, 2014. (Accessed 17/4/2015, at http://thescoopblog.dallasnews.com/2014/10/starting-today-dallas-animal-services-will-begin-testing-nina-phams-year-old-dog-bentley-for-ebola.html/.)
    13. EBOLAVIRUS, ANIMAL RESERVOIR (05): USA, DOG, NOT. 2014. (Accessed 01/05/2015, at http://promedmail.org/direct.php?id=20141026.2901733 )
    14. Barrette RW, Metwally SA, Rowland JM, et al. Discovery of swine as a host for the Reston ebolavirus. Science 2009;325:204-6.
    15. Rouquet P, Froment JM, Bermejo M, et al. Wild animal mortality monitoring and human Ebola outbreaks, Gabon and Republic of Congo, 2001-2003. Emerg Infect Dis 2005;11:283-90.
    16. Kudoyarova-Zubavichene NM, Sergeyev NN, Chepurnov AA, Netesov SV. Preparation and use of hyperimmune serum for prophylaxis and therapy of Ebola virus infections. J Infect Dis 1999;179 Suppl 1:S218-23.
    17. Bray M, Davis K, Geisbert T, Schmaljohn C, Huggins J. A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J Infect Dis 1998;178:651-61.
    18. Ebihara H, Takada A, Kobasa D, et al. Molecular determinants of Ebola virus virulence in mice. PLoS Pathog 2006;2:e73.
    19. Geisbert TW, Young HA, Jahrling PB, Davis KJ, Kagan E, Hensley LE. Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event. J Infect Dis 2003;188:1618-29.
    20. Turell MJ, Bressler DS, Rossi CA. Short report: lack of virus replication in arthropods after intrathoracic inoculation of Ebola Reston virus. Am J Trop Med Hyg 1996;55:89-90.
    21. Swanepoel R, Leman PA, Burt FJ, et al. Experimental inoculation of plants and animals with Ebola virus. Emerg Infect Dis 1996;2:321-5.
    22. Ebola haemorrhagic fever in Sudan, 1976. Report of a WHO/International Study Team. Bull World Health Organ 1978;56:247-70.
    23. Miranda ME, Ksiazek TG, Retuya TJ, Khan AS, Sanchez A, Fulhorst CF, Rollin PE, Calaor AB, Manalo DL, Roces MC, Dayrit MM, Peters CJ. Epidemiology of Ebola (subtype Reston) virus in the Philippines. J Infect Dis. 1999 Feb;179 Suppl 1:S115-9.

      Ebola Returns To Liberia With A Mysterious Case Near Monrovia

      Almost two months after Liberia was declared Ebola-free, the disease has cropped up again — this time in a rural town outside the capital city.
      So far, there's only one new case, but health officials are rushing to stop its spread.
      Liberia's deputy health minister, Tolbert Nyenswah, said Tuesday that a 17-year-old boy died of Ebola at his home in Nedowein, a village near the country's international airport.
      "There is no need to panic. The corpse has been buried, and our contact tracing has started work," Nyenswah told Reuters. Health officials have already started quarantining homes near where the body was found.
      But there are a few reasons why the case is worrisome.
      First, it's not known where or how the teenager caught Ebola. "There is no known source of infection, and there's no information about him traveling to Guinea or SL [Sierra Leone]," the ministry of health told Science magazine in an email.
      Second, health officials didn't know the teenager had Ebola until after he died. So he could have unwittingly spread the disease to his family and caretakers.
      Finally, many international aid groups have left Liberia since cases plummeted to zero back in March. The case will test Liberia's ability to stop an outbreak largely on its own.
      The World Health Organization declared the country Ebola-free May 9. But neighboring countries Guinea and Sierra Leone are still struggling to stop the virus. Last week, the two countries reported 20 cases total, the WHO said.
      Since Ebola erupted in West Africa, there have been 27,443 reported cases, More than 11,000 people have died.

      [Original Article]

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